SCIENTIFIC PUBLICATIONS
FX06-COVID: Verbesserung der Oxygenierung durch FX06 in Intensivpatienten mit schweren Verläufen von COVID-19
K. Zacharowski · Studiengruppe FX06-COVID
Der Anaesthesist, published online: October 01, 2020
Fibrin-derived peptide Bβ15-42 (FX06) as salvage treatment in critically ill patients with COVID-19-associated acute respiratory distress syndrome
Elisabeth H. Adam, Benedikt Schmid, Michael Sonntagbauer, Peter Kranke, Kai Zacharowski, Patrick Meybohm
Critical Care 2020, 24), 574
Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice
Jonna B. Westover, Brady T. Hickerson, Arnaud J. Van Wettere, Brett L. Hurst, Jacqueline P. Kurz, Ashley Dagley, Petra Wülfroth, Takashi Komeno, Yousuke Furuta, Thomas Steiner, Brian B. Gowen
Pathogens 2019, 8(4), 158
[Full text: https://doi.org/10.3390/pathogens8040158]
Combined peri-ischemic administration of Bß15–42 in treating ischemia reperfusion injury of the mouse kidney
Anja Urbschat, Katrin Rupprecht, Kai Zacharowski, Nicholas Obermüller, Bertram Scheller, Johannes Holfeld, Can Tepeköylü, Rainer Hofmann, Patrick Paulus
Microvascular Research 2015, 101, 48–54
[Abstract: https://www.ncbi.nlm.nih.gov/pubmed/26116861]
The Fibrin-Derived Peptide Bß15-42 (FX06) Ameliorates Vascular Leakage and Improves Survival and Neurocognitive Recovery: Implications From Two Animal Models of Cardiopulmonary Resuscitation
Bergt S1, Gruenewald M, Beltschany C, Grub A, Neumann T, Albrecht M, Vollmar B, Zacharowski K, Roesner JP, Meybohm P.
Crit Care Med. 2016 Oct;44(10):e988-95. doi: 10.1097/CCM.0000000000001860
Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care
Timo Wolf, Gerrit Kann, Prof Stephan Becker, Christoph Stephan, Hans-Reinhardt Brodt, Philipp de Leuw, Thomas Grünewald, Thomas Vogl, Prof Volkhard A J Kempf, Prof Oliver T Keppler, Prof Kai Zacharowski
The Lancet 2015, 385, 9976, 1428–1435
The Small Fibrinopeptide Bß15–42 as Renoprotective Agent Preserving the Endothelial and Vascular Integrity in Early Ischemia Reperfusion Injury in the Mouse Kidney
Anja Urbschat, Kai Zacharowski, Nicholas Obermüller, Katrin Rupprecht, Daniela Penzkofer, Carla Jennewein, Nguyen Tran, Bertram Scheller, Stefanie Dimmeler, Patrick Paulus
PLOS one January 02, 2014 | DOI: 10.1371/journal.pone.0084432
The fibrin-derived peptide Bß15-42 attenuates liver damage in a rat model of liver ischemia/reperfusion injury.
Liu A, Fang H, Yang Y, Sun J, Fan H, Liu S, Dirsch O, Dahmen U
Shock, 2013, 39, 397-403
Effect of a vascular endothelial cadherin antagonist on graft function in a rat lung transplant model
Tian Z, Dong B, Blackwell J, Egan TM
Ann Thorac. Surg., 2013, 95, 1028–1033
The fibrinopeptide Bß15-42 reduces inflammation in mice subjected to polymicrobial sepsis
Jennewein C, Mehring M, Tran N, Paulus P, Ockelmann PA, Habeck K, Latsch K, Scheller B, Zacharowski K, Mutlak H.
Shock, 2012, 38, 275-280
Structural basis of single molecular heparin-FX06 interaction revealed by SPM measurements and molecular simulations
Guo C, Wang B, Wang L, Xu B
Chem. Commun., 2012, 48, 12222–12224
Linking inflammation and coagulation: novel drug targets to treat organ ischemia
Jennewein C, Paulus P, Zacharowski K
Current Opinion in Anaesthesiology, 2011, 24(4):375-380
Quantification of elemental labeled peptides in cellular uptake studies
Koellensperger G, Groeger M, Zinkl D, Petzelbauer P, Hann S
J. Anal. At. Spectrom., 2009, 24, 97–102
Peptide Bß15-42 Preserves Endothelial Barrier Function in Shock
Gröger M, Pasteiner W, Ignatyev G, Matt U, Knapp S, Atrasheuskaya A, Bukin E, Friedl P, Zinkl D, Hofer-Warbinek R, Zacharowski K, Petzelbauer P, Reingruber S
PLoS ONE 4(4): e5391. doi:10.1371/journal.pone.0005391
Effect of intravenous FX06 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction
Results of the F.I.R.E. (Efficacy of FX06 in the prevention of myocardial reperfusion injury) trial
Atar D, Petzelbauer P, Schwitter J, Huber K, Rensing B, Kasprzak JD, Butter C, Grip L, Hansen PR, Süselbeck T, Clemmensen PM, Marin-Galiano M, Geudelin B, Buser BT, for the F.I.R.E. Investigators
Journal of the American College of Cardiology (2009) 53:720-729
Bß15-42 (FX06) reduces pulmonary, myocardial, liver, and small intestine damage in a pig model of hemorrhagic shock and reperfusion
Roesner JP, Petzelbauer P, Koch A, Tran N, Iber T, Vagts DA, Scheeren TWL, Vollmar B, Nöldge-Schomburg GEF, Zacharowski, K
Crit Care Med 2009 Vol. 37, No. 2
A double blind, single centre, sub-chronic reperfusion trial evaluating FX06 following haemorrhagic shock in pigs
Roesner JP, Petzelbauer P, Koch A, Tran N, Iber T, Mutz C, Vollmar B, Nöldge-Schomburg GEF, Zacharowski K
Resuscitation 2009; 80:264–271
The fibrin-derived peptide Bbeta15-42 is cardioprotective in a pig model of myocardial ischemia-reperfusion injury
Roesner JP, Petzelbauer P, Koch A, Mersmann J, Zacharowski PA, Boehm O, Reingruber S, Pasteiner W, Mascher HD, Wolzt M, Barthuber C, Noldge-Schomburg GE, Scheeren TW, Zacharowski K
Crit Care Med. 2007 May 22
The effects of the fibrin-derived peptide Bbeta15-42 in acute and chronic rodent models of myocardial ischemia-reperfusion
Zacharowski K, Zacharowski PA, Friedl P, Mastan P, Koch A, Boehm O, Rother RP, Reingruber S, Henning R, Emeis JJ, Petzelbauer P
Shock. 2007 Jun;27(6):631-63
Neue Überlegungen zu Entzündung und Gerinnung
[New reflections on inflammation and coagulation]
[New reflections on inflammation and coagulation]
Zacharowski, K
Der Anaesthesist. 2007 Mar 16 (DOI: 10.1007/s00101-007-1163-3)
FX06 (fibrin-derived peptide Bbeta15-42) - A potential candidate for myocardial reperfusion therapy
Henning R, Zacharowski K, Petzelbauer P
Drugs Fut. 2006, 31(9):811-818 (DOI: 10.1358/dof.2006.031.09.1025670)
Rationale and Design of the 'F.I.R.E.' Study.
A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Measure the Effect of FX06 (a Fibrin-Derived Peptide Bbeta(15-42)) on Ischemia-Reperfusion Injury in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.
A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Measure the Effect of FX06 (a Fibrin-Derived Peptide Bbeta(15-42)) on Ischemia-Reperfusion Injury in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.
Atar D, Huber K, Rupprecht HJ, Kopecky SL, Schwitter J, Theek C, Brandl K, Henning R, Geudelin B.
Cardiology 2006 Oct 2;108(2):117-123 (DOI: 10.1159/000095982)
Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction
Zacharowski K, Zacharowski P, Reingruber S, Petzelbauer P
J. Mol. Med. 2006 June;84(6):469-477
The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury.
Petzelbauer P, Zacharowski PA, Miyazaki Y, Friedl P, Wickenhauser G, Castellino FJ, Groger M, Wolff K, Zacharowski K.
Nat. Med. 2005 Mar;11(3):298-304
[Original Article: www.nature.com/nm/journal/v11/n3/full/nm1198.html]
