Scientific Publications - F4-Pharma

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Unlocking endothelial barrier restoration: FX06 in systemic capillary leak syndrome and beyond
Maddalena Alessandra Wu, Laura Locatelli, Chiara Cogliati, Riccardo Colombo, Jeanette A. Maier

Biomedicine & Pharmacotherapy 171 (2024), 116147

Microvascular Leakage as Therapeutic Target for Ischemia and Reperfusion Injury

Kloka, Jan Andreas, Benjamin Friedrichson, Petra Wülfroth, Rainer Henning, Kai Zacharowski

Cells 12, no. 10: 1345, 2023

FX06-COVID: Verbesserung der Oxygenierung durch FX06 in Intensivpatienten mit schweren Verläufen von COVID-19

K. Zacharowski · Studiengruppe FX06-COVID

Der Anaesthesist, published online: October 01, 2020

Fibrin-derived peptide Bβ15-42 (FX06) as salvage treatment in critically ill patients with COVID-19-associated acute respiratory distress syndrome

Elisabeth H. Adam, Benedikt Schmid, Michael Sonntagbauer, Peter Kranke, Kai Zacharowski, Patrick Meybohm

Critical Care 2020, 24), 574

Ebola Hemorrhagic Shock Syndrome-on-a-Chip

Abidemi Junaid, Huaqi Tang, Anne van Reeuwijk, ..., Anton Jan van Zonneveld, Thomas Hankemeier, Alireza Mashaghi

iScience 23, 100765, 2019

Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia Syndrome Virus Infection in Mice

Jonna B. Westover, Brady T. Hickerson,  Arnaud J. Van Wettere, Brett L. Hurst, Jacqueline P. Kurz, Ashley Dagley, Petra Wülfroth, Takashi Komeno, Yousuke Furuta, Thomas Steiner, Brian B. Gowen

Pathogens 2019, 8(4), 158

Combined peri-ischemic administration of Bß15–42 in treating ischemia reperfusion injury of the mouse kidney

Anja Urbschat, Katrin Rupprecht, Kai Zacharowski, Nicholas Obermüller, Bertram Scheller, Johannes Holfeld, Can Tepeköylü, Rainer Hofmann, Patrick Paulus

Microvascular Research 2015, 101, 48–54

The Fibrin-Derived Peptide Bß15-42 (FX06) Ameliorates Vascular Leakage and Improves Survival and Neurocognitive Recovery: Implications From Two Animal Models of Cardiopulmonary Resuscitation

Bergt S1, Gruenewald M, Beltschany C, Grub A, Neumann T, Albrecht M, Vollmar B, Zacharowski K, Roesner JP, Meybohm P.

Crit Care Med. 2016 Oct;44(10):e988-95. doi: 10.1097/CCM.0000000000001860

Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care

Timo Wolf, Gerrit Kann, Prof Stephan Becker, Christoph Stephan, Hans-Reinhardt Brodt, Philipp de Leuw, Thomas Grünewald, Thomas Vogl, Prof Volkhard A J Kempf, Prof Oliver T Keppler, Prof Kai Zacharowski

The Lancet 2015, 385, 9976, 1428–1435

The Small Fibrinopeptide Bß15–42 as Renoprotective Agent Preserving the Endothelial and Vascular Integrity in Early Ischemia Reperfusion Injury in the Mouse Kidney

Anja Urbschat, Kai Zacharowski, Nicholas Obermüller, Katrin Rupprecht, Daniela Penzkofer, Carla Jennewein, Nguyen Tran, Bertram Scheller, Stefanie Dimmeler, Patrick Paulus

PLOS one January 02, 2014 | DOI: 10.1371/journal.pone.0084432

The fibrin-derived peptide Bß15-42 attenuates liver damage in a rat model of liver ischemia/reperfusion injury.

Liu A, Fang H, Yang Y, Sun J, Fan H, Liu S, Dirsch O, Dahmen U

Shock, 2013, 39, 397-403

Effect of a vascular endothelial cadherin antagonist on graft function in a rat lung transplant model

Tian Z, Dong B, Blackwell J, Egan TM

Ann Thorac. Surg., 2013, 95, 1028–1033

The fibrinopeptide Bß15-42 reduces inflammation in mice subjected to polymicrobial sepsis

Jennewein C, Mehring M, Tran N, Paulus P, Ockelmann PA, Habeck K, Latsch K, Scheller B, Zacharowski K, Mutlak H.

Shock, 2012, 38, 275-280

Structural basis of single molecular heparin-FX06 interaction revealed by SPM measurements and molecular simulations

Guo C, Wang B, Wang L, Xu B

Chem. Commun., 2012, 48, 12222–12224

Linking inflammation and coagulation: novel drug targets to treat organ ischemia

Jennewein C, Paulus P, Zacharowski K

Current Opinion in Anaesthesiology, 2011, 24(4):375-380

Quantification of elemental labeled peptides in cellular uptake studies

Koellensperger G, Groeger M, Zinkl D, Petzelbauer P, Hann S

J. Anal. At. Spectrom., 2009, 24, 97–102

Peptide Bß15-42 Preserves Endothelial Barrier Function in Shock

Gröger M, Pasteiner W, Ignatyev G, Matt U, Knapp S, Atrasheuskaya A, Bukin E, Friedl P, Zinkl D, Hofer-Warbinek R, Zacharowski K, Petzelbauer P, Reingruber S

PLoS ONE 4(4): e5391. doi:10.1371/journal.pone.0005391

Effect of intravenous FX06 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction
Results of the F.I.R.E. (Efficacy of FX06 in the prevention of myocardial reperfusion injury) trial

Atar D, Petzelbauer P, Schwitter J, Huber K, Rensing B, Kasprzak JD, Butter C, Grip L, Hansen PR, Süselbeck T, Clemmensen PM, Marin-Galiano M, Geudelin B, Buser BT, for the F.I.R.E. Investigators

Journal of the American College of Cardiology (2009) 53:720-729

15-42 (FX06) reduces pulmonary, myocardial, liver, and small intestine damage in a pig model of hemorrhagic shock and reperfusion

Roesner JP, Petzelbauer P, Koch A, Tran N, Iber T, Vagts DA, Scheeren TWL, Vollmar B, Nöldge-Schomburg GEF, Zacharowski, K

Crit Care Med 2009 Vol. 37, No. 2

A double blind, single centre, sub-chronic reperfusion trial evaluating FX06 following haemorrhagic shock in pigs

Roesner JP, Petzelbauer P, Koch A, Tran N, Iber T, Mutz C, Vollmar B, Nöldge-Schomburg GEF, Zacharowski K

Resuscitation 2009; 80:264–271

The fibrin-derived peptide Bbeta15-42 is cardioprotective in a pig model of myocardial ischemia-reperfusion injury

Roesner JP, Petzelbauer P, Koch A, Mersmann J, Zacharowski PA,  Boehm O, Reingruber S, Pasteiner W, Mascher HD, Wolzt M, Barthuber C, Noldge-Schomburg GE, Scheeren TW, Zacharowski K

Crit Care Med. 2007 May 22

The effects of the fibrin-derived peptide Bbeta15-42 in acute and chronic rodent models of myocardial ischemia-reperfusion

Zacharowski K, Zacharowski PA, Friedl P, Mastan P, Koch A, Boehm O, Rother RP, Reingruber S, Henning R, Emeis JJ, Petzelbauer P

Shock. 2007 Jun;27(6):631-63

Neue Überlegungen zu Entzündung und Gerinnung
[New reflections on inflammation and coagulation]
Zacharowski, K

Der Anaesthesist. 2007 Mar 16 (DOI: 10.1007/s00101-007-1163-3)

FX06 (fibrin-derived peptide Bbeta15-42) - A potential candidate for myocardial reperfusion therapy

Henning R, Zacharowski K, Petzelbauer P

Drugs Fut. 2006, 31(9):811-818 (DOI: 10.1358/dof.2006.031.09.1025670)

Rationale and Design of the 'F.I.R.E.' Study.
A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Measure the Effect of FX06 (a Fibrin-Derived Peptide Bbeta(15-42)) on Ischemia-Reperfusion Injury in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

Atar D, Huber K, Rupprecht HJ, Kopecky SL, Schwitter J, Theek C, Brandl K, Henning R, Geudelin B.

Cardiology 2006 Oct 2;108(2):117-123 (DOI: 10.1159/000095982)

Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction

Zacharowski K, Zacharowski P, Reingruber S, Petzelbauer P

J. Mol. Med. 2006 June;84(6):469-477

The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury.

Petzelbauer P, Zacharowski PA, Miyazaki Y, Friedl P, Wickenhauser G, Castellino FJ, Groger M, Wolff K, Zacharowski K.

Nat. Med. 2005 Mar;11(3):298-304

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Page modified: February 23, 2024
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