Mode of Action - F4-Pharma

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FX06 has a three-pronged effect on the microvasculature:

  1. It prevents the transmigration of leukocytes by antagonizing pro-inflammatory fibrin E1 fragment. Thereby an acute inflammatory reaction is stopped in its tracks with the consequence of a reduction in tissue damage.

  2. It stabilizes the endothelial barrier function by preventing stress-induced rearrangement of the endothelial cell actin cytoskeleton. The consequence is the prevention of edema formation.

  3. It antagonizes vasoconstrictive signals induced by a number of mediators. The consequence is a reduction of arteriolar spasm, which in conjunction with the edema is a hallmark of microvascular dysfunction.
Mode of action
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Page modified: February 23, 2024
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