F4 Pharma


Mode of Action

F4 Pharma has conclusively demonstrated that leukocyte transmigration is critically controlled by fibrin fragments. These short lived intermediates engage leukocytes to the endothelial cell junction, which breaks up the VE-cadherin interaction between neighbouring endothelial cells. This interaction allows the leukocyte to pass through into the tissue (diapedesis).

Mode of action
Mode of action

F4 Pharma´s anti-inflammatory peptide FX06 prevents this interaction between fibrin fragments and VE-cadherin.

[Disease Applications >]


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