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NEWS: Publications

Combined peri-ischemic administration of Bß15–42 in treating ischemia reperfusion injury of the mouse kidney

Anja Urbschat, Katrin Rupprecht, Kai Zacharowski, Nicholas Obermüller, Bertram Scheller, Johannes Holfeld, Can Tepeköylü, Rainer Hofmann, Patrick Paulus

Microvascular Research 2015, 101, 48–54

[Abstract: www.sciencedirect.com/science/article/pii/S0026286215300029?via%3Dihub >>]

The Fibrin-Derived Peptide Bß15-42 (FX06) Ameliorates Vascular Leakage and Improves Survival and Neurocognitive Recovery: Implications From Two Animal Models of Cardiopulmonary Resuscitation

Bergt S1, Gruenewald M, Beltschany C, Grub A, Neumann T, Albrecht M, Vollmar B, Zacharowski K,
Roesner JP, Meybohm P.

Crit Care Med. 2016 Oct;44(10):e988-95. doi: 10.1097/CCM.0000000000001860

[Abstract: http://journals.lww.com/ccmjournal/Abstract/2016/10000/
The_Fibrin_Derived_Peptide_B_15_42__FX06_.41.aspx >>

The LancetSevere Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care

Timo Wolf, Gerrit Kann, Prof Stephan Becker, Christoph Stephan, Hans-Reinhardt Brodt, Philipp de
Leuw, Thomas Grünewald, Thomas Vogl, Prof Volkhard A J Kempf, Prof Oliver T Keppler,
Prof Kai Zacharowski

The Lancet 2015, 385, 9976, 1428–1435

[Full text: www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)62384-9/fulltext >>]

PLOS one LogoThe Small Fibrinopeptide Bß15–42 as Renoprotective Agent Preserving the Endothelial and Vascular Integrity in Early Ischemia Reperfusion Injury in the Mouse Kidney

Anja Urbschat, Kai Zacharowski, Nicholas Obermüller, Katrin Rupprecht, Daniela Penzkofer,
Carla Jennewein, Nguyen Tran, Bertram Scheller, Stefanie Dimmeler, Patrick Paulus

PLOS one January 02, 2014 | DOI: 10.1371/journal.pone.0084432


Shock cover
The fibrin-derived peptide Bß15-42 attenuates liver damage in a rat model of liver ischemia/reperfusion injury.

Liu A, Fang H, Yang Y, Sun J, Fan H, Liu S, Dirsch O, Dahmen U

Shock, 2013, 39, 397-403

[Abstract: http://journals.lww.com/shockjournal/Abstract/2013/04000/
The_Fibrin_Derived_Peptide_B_15_42_Attenuates.11.aspx >>

Ann Thorac. Surg. cover
Effect of a vascular endothelial cadherin antagonist on graft function in a rat lung transplant model

Tian Z, Dong B, Blackwell J, Egan TM

Ann Thorac. Surg., 2013, 95, 1028–1033

[Abstract: http://ats.ctsnetjournals.org/cgi/content/full/95/3/1028 >>]

Shock coverThe fibrinopeptide Bß15-42 reduces inflammation in mice subjected to polymicrobial sepsis

Jennewein C, Mehring M, Tran N, Paulus P, Ockelmann PA, Habeck K, Latsch K, Scheller B, Zacharowski K, Mutlak H.

Shock. 2012, 38, 275-280

[Abstract: http://journals.lww.com/shockjournal/Abstract/2012/09000/
The_Fibrinopeptide_B_15_42_Reduces_Inflammation_in.7.aspx >>

Chem. Commun. coverStructural basis of single molecular heparin-FX06 interaction revealed by SPM measurements and molecular simulations

Guo C, Wang B, Wang L, Xu B

Chem. Commun., 2012, 48, 12222–12224

[Abstract: http://pubs.rsc.org/en/content/articlelanding/2012/cc/c2cc36546d >>]

Curr_Op_Anestesiology coverLinking inflammation and coagulation: novel drug targets to treat organ ischemia

Jennewein C, Paulus P, Zacharowski K

Current Opinion in Anaesthesiology, 2011, 24(4):375-380

[Abstract: http://journals.lww.com/co-anesthesiology/Abstract/2011/08000/
Linking_inflammation_and_coagulation___novel_drug.4.aspx >>

JAAS coverQuantification of elemental labeled peptides in cellular uptake studies

Koellensperger G, Groeger M, Zinkl D, Petzelbauer P, Hann S

J. Anal. At. Spectrom., 2009, 24, 97–102

[pdf-file in new window (380 KB) >>] or [Original Article in 'JAAS' (subscription required) >>]

PLoS one LogoPeptide Bß15-42 Preserves Endothelial Barrier Function in Shock

Gröger M, Pasteiner W, Ignatyev G, Matt U, Knapp S, Atrasheuskaya A, Bukin E, Friedl P, Zinkl D, Hofer-Warbinek R, Zacharowski K, Petzelbauer P, Reingruber S

PLoS ONE 4(4): e5391. doi:10.1371/journal.pone.0005391

[pdf-file in new window (3,2 MB) >>] or [go to PLoS ONE >>]

JACC coverEffect of intravenous FX06 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction

Results of the F.I.R.E. (Efficacy of FX06 in the prevention of myocardial reperfusion injury) trial

Atar D, Petzelbauer P, Schwitter J, Huber K, Rensing B, Kasprzak JD, Butter C, Grip L, Hansen PR, Süselbeck T, Clemmensen PM, Marin-Galiano M, Geudelin B, Buser BT, for the F.I.R.E. Investigators

Journal of the American College of Cardiology (2009) 53:720-729

[pdf-file in new window>>]

Cover Crit Care Med15-42 (FX06) reduces pulmonary, myocardial, liver, and small intestine damage in a pig model of hemorrhagic shock and reperfusion

Roesner JP, Petzelbauer P, Koch A, Tran N, Iber T, Vagts DA, Scheeren TWL, Vollmar B, Nöldge-Schomburg GEF, Zacharowski, K

Crit Care Med 2009 Vol. 37, No. 2

[pdf-file in new window >>]

ResuscitationA double blind, single centre, sub-chronic reperfusion trial evaluating FX06 following haemorrhagic shock in pigs

Roesner JP, Petzelbauer P, Koch A, Tran N, Iber T, Mutz C, Vollmar B, Nöldge-Schomburg GEF, Zacharowski K

Resuscitation 2009; 80:264–271

[pdf-file in new window >>]

Cover Crit Care Med
The fibrin-derived peptide Bbeta15-42 is cardioprotective in a pig model of myocardial ischemia-reperfusion injury

Roesner JP, Petzelbauer P, Koch A, Mersmann J, Zacharowski PA, Boehm O, Reingruber S, Pasteiner W, Mascher HD, Wolzt M, Barthuber C, Noldge-Schomburg GE, Scheeren TW, Zacharowski K

Crit Care Med. 2007 May 22, Epub Ahead of Print

[PubMed Abstract >>]   [Original Article in 'Critical Care Medicine' (subscription required) >>]

Cover Shock
The effects of the fibrin-derived peptide Bbeta15-42 in acute and chronic rodent models of myocardial ischemia-reperfusion

Zacharowski K, Zacharowski PA, Friedl P, Mastan P, Koch A, Boehm O, Rother RP, Reingruber S, Henning R, Emeis JJ, Petzelbauer P

Shock. 2007 Jun;27(6):631-63

[PubMed Abstract >>]   [Original Article in 'Shock' >>]

Cover Der Anaesthesist
Neue Überlegungen zu Entzündung und Gerinnung
[New reflections on inflammation and coagulation]

Zacharowski, K

Der Anaesthesist. 2007 Mar 16 (DOI: 10.1007/s00101-007-1163-3)

[PubMed Abstract >>]   [Original Article in 'Der Anaesthesist' (subscription required) >>]

Cover Drugs of the Future
FX06 (fibrin-derived peptide Bbeta15-42) - A potential candidate for myocardial reperfusion therapy

Henning R, Zacharowski K, Petzelbauer P

Drugs Fut. 2006, 31(9):811-818 (DOI: 10.1358/dof.2006.031.09.1025670)

[Abstract >>]   [Original Article in 'Drugs of the Future' (subscription required) >>]

Cover Cardiology
Rationale and Design of the 'F.I.R.E.' Study.
A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Measure the Effect of FX06 (a Fibrin-Derived Peptide Bbeta(15-42)) on Ischemia-Reperfusion Injury in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

Atar D, Huber K, Rupprecht HJ, Kopecky SL, Schwitter J, Theek C, Brandl K, Henning R, Geudelin B.

Cardiology 2006 Oct 2;108(2):117-123 (DOI: 10.1159/000095982)

[PubMed Abstract >>]   [Original Article in 'Cardiology' (subscription required) >>]

Cover J. Mol. Med.
Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction

Zacharowski K, Zacharowski P, Reingruber S, Petzelbauer P

J. Mol. Med. 2006 June;84(6):469-477

[PubMed Abstract >>]   [Original Article in 'J. Mol. Med.' (subscription required) >>]

Nature Medicine Cover 3/05
The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury.

Petzelbauer P, Zacharowski PA, Miyazaki Y, Friedl P, Wickenhauser G, Castellino FJ, Groger M, Wolff K, Zacharowski K.

Nat. Med. 2005 Mar;11(3):298-304

[Original Article in 'Nature Medicine': www.nature.com/nm/journal/v11/n3/full/nm1198.html >>]


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